A Research Laboratory of Neuroimmunology, Neurotrauma, and Behavior
Dunni Adekunle-Adegbite (2018-Current)
B.S. Microbiology, Biological Sciences Scholars
Peer-Reviewed Publications:
Sweeney N, Kim TY, Morrison CT, Li L, Acosta D, Liang J, Datla NV, Fitzgerald JA, Huang H, Liu X, Tan GH, Wu M, Karelina K, Bray CE, Weil ZM, Scharre DW, Serrano GE, Saito T, Saido TC, Beach TG, Kokiko-Cochran ON, Godbout JP, Johnson GVW, Fu H (2024). Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway. Acta Neuropathol. 2024 Oct 11;148(1):52. doi: 10.1007/s00401-024-02810-1.
Goodman EJ, DiSabato DJ, Sheridan JF, Godbout JP (2024). Novel microglial transcriptional signatures promote social and cognitive deficits following repeated social defeat. Commun Biol. 2024 Sep 28;7(1):1199. doi: 10.1038/s42003-024-06898-9.
Brennan FH, Swarts EA, Kigerl KA, Mifflin KA, Guan Z, Noble BT, Wang Y, Witcher KG, Godbout JP, Popovich PG (2024). Microglia promote maladaptive plasticity in autonomic circuitry after spinal cord injury in mice. Sci Transl Med. 2024 Jun 12;16(751):eadi3259. doi: 10.1126/scitranslmed.adi3259. Epub 2024 Jun 12.
Goodman EJ, Biltz RG, Packer JM, DiSabato DJ, Swanson SP, Oliver B, Quan N, Sheridan JF, Godbout JP (2024). Enhanced fear memory after social defeat in mice is dependent on interleukin-1 receptor signaling in glutamatergic neurons. Mol Psychiatry. 2024 Aug;29(8):2321-2334. doi: 10.1038/s41380-024-02456-1. Epub 2024 Mar 8.
Packer JM, Bray CE, Beckman NB, Wangler LM, Davis AC, Goodman EJ, Klingele NE, Godbout JP (2024). Impaired cortical neuronal homeostasis and cognition after diffuse traumatic brain injury are dependent on microglia and type I interferon responses. Glia. 2024 Feb;72(2):300-321. doi: 10.1002/glia.24475. Epub 2023 Nov 8.
Biltz RG, Swanson SP, Draime N, Davis AC, Yin W, Goodman EJ, Gallagher NR, Bhattacharya A, Sheridan JF, Godbout JP (2024). Antagonism of the brain P2X7 ion channel attenuates repeated social defeat induced microglia reactivity, monocyte recruitment and anxiety-like behavior in male mice. Brain Behav Immun. 2024 Jan;115:356-373. doi: 10.1016/j.bbi.2023.10.011. Epub 2023 Oct 31.
Wangler LM, Godbout JP (2023). Microglia moonlighting after traumatic brain injury: aging and interferons influence chronic microglia reactivity. Trends Neurosci. 2023 Nov;46(11):926-940. doi: 10.1016/j.tins.2023.08.008. Epub 2023 Sep 16. Review.
Otto-Dobos LD, Santos JC, Strehle LD, Grant CV, Simon LA, Oliver B, Godbout JP, Sheridan JF, Barrientos RM, Glasper ER, Pyter LM (2023). The role of microglia in 67NR mammary tumor-induced suppression of brain responses to immune challenges in female mice. J Neurochem. 2024 Oct;168(10):3482-3499. doi: 10.1111/jnc.15830. Epub 2023 May 10.
Butler MJ, Sengupta S, Muscat SM, Amici SA, Biltz RG, Deems NP, Dravid P, Mackey-Alfonso S, Ijaz H, Bettes MN, Godbout JP, Kapoor A, Guerau-de-Arellano M, Barrientos RM (2023). CD8+ T cells contribute to diet-induced memory deficits in aged male rats. Brain Behav Immun. 2023 Feb 9;109:235-250. doi: 10.1016/j.bbi.2023.02.003. Epub 2023 Mar 31.
Biltz RG, Sawicki CM, Sheridan JF, Godbout JP (2022). The neuroimmunology of social-stress-induced sensitization. Nat Immunol. 2022 Nov 11. doi: 10.1038/s41590-022-01321-z. Epub 2022 Nov 11. Review.
DiSabato DJ, Yin W, Biltz RG, Gallagher NR, Oliver B, Nemeth DP, Liu X, Sheridan JF, Quan N, Godbout JP (2022). IL-1 Receptor-1 on Vglut2+ neurons in the hippocampus is critical for neuronal and behavioral sensitization after repeated social stress. Brain, Behavior, & Immunity - Health. 29 October 2022. Volume 26 (Cover date: December 2022).
Wangler LM, Bray CE, Packer JM, Tapp ZM, Davis AC, O'Neil SM, Baetz K, Ouviña M, Witzel M, Godbout JP (2022). Amplified Gliosis and Interferon-Associated Inflammation in the Aging Brain Following Diffuse Traumatic Brain Injury. J Neurosci. 2022 Oct 17:JN-RM-1377-22. doi: 10.1523/JNEUROSCI.1377-22.2022. Epub 2022 Oct 18.
Yin W, Swanson SP, Biltz RG, Goodman EJ, Gallagher NR, Sheridan JF, Godbout JP (2022). Unique brain endothelial profiles activated by social stress promote cell adhesion, prostaglandin E2 signaling, hypothalamic-pituitary-adrenal axis modulation, and anxiety. Neuropsychopharmacology. 2022 Dec;47(13):2271-2282. doi: 10.1038/s41386-022-01434-x. Epub 2022 Sep 14.
Rodocker HI, Bordbar A, Larson MJE, Biltz RG, Wangler L, Fadda P, Godbout JP, Tedeschi A (2022). Breaking Mental Barriers Promotes Recovery After Spinal Cord Injury. Front Mol Neurosci. 2022 Jul 7;15:868563. doi: 10.3389/fnmol.2022.868563. eCollection 2022.
Brennan FH, Li Y, Wang C, Ma A, Guo Q, Li Y, Pukos N, Campbell WA, Witcher KG, Guan Z, Kigerl KA, Hall JCE, Godbout JP, Fischer AJ, McTigue DM, He Z, Ma Q, Popovich PG (2022). Microglia coordinate cellular interactions during spinal cord repair in mice. Nat Commun. 2022 Jul 14;13(1):4096. doi: 10.1038/s41467-022-31797-0.
Bray CE, Witcher KG, Adekunle-Adegbite D, Ouvina M, Witzel M, Hans E, Tapp ZM, Packer J, Goodman E, Zhao F, Chunchai T, O'Neil S, Chattipakorn SC, Sheridan J, Kokiko-Cochran ON, Askwith C, Godbout JP (2022). Chronic Cortical Inflammation, Cognitive Impairment and Immune Reactivity Associated with Diffuse Brain Injury are Ameliorated by Forced Turnover of Microglia. J Neurosci. 2022 May 18;42(20):4215-4228. doi: 10.1523/JNEUROSCI.1910-21.2022. Epub 2022 Apr 19.
Tapp ZM, Cornelius S, Oberster A, Kumar JE, Atluri R, Witcher KG, Oliver B, Bray C, Velasquez J, Zhao F, Peng J, Sheridan J, Askwith C, Godbout JP, Kokiko-Cochran ON (2022). Sleep fragmentation engages stress-responsive circuitry, enhances inflammation and compromises hippocampal function following traumatic brain injury. Exp Neurol. 2022 Jul;353:114058. doi: 10.1016/j.expneurol.2022.114058. Epub 2022 Mar 28.
Nemeth DP, Liu X, McKim DB, DiSabato DJ, Oliver B, Herd A, Katta A, Negray CE, Floyd J, McGovern S, Pruden PS, Zhutang F, Smirnova M, Godbout JP, Sheridan J, Quan N (2022). Dynamic Interleukin-1 Receptor Type 1 Signaling Mediates Microglia-Vasculature Interactions Following Repeated Systemic LPS. J Inflamm Res. 2022 Mar 4;15:1575-1590. doi: 10.2147/JIR.S350114. eCollection 2022.
Jaggers RM, DiSabato DJ, Loman BR, Kontic D, Spencer KD, Allen JM, Godbout JP, Quan N, Gur TL, Bailey MT (2022). Stressor-Induced Reduction in Cognitive Behavior is Associated with Impaired Colonic Mucus Layer Integrity and is Dependent Upon the LPS-Binding Protein Receptor CD14. J Inflamm Res. 2022 Mar 3;15:1617-1635. doi: 10.2147/JIR.S332793. eCollection 2022.
O'Neil SM, Hans EE, Jiang S, Wangler LM, & Godbout JP (2022). Astrocyte immunosenescence and deficits in interleukin 10 signaling in the aged brain disrupt the regulation of microglia following innate immune activation. Glia. 2022 May;70(5):913-934. doi: 10.1002/glia.24147. Epub 2022 Jan 21.
Navarro, E., Norden, D. M., Trojanowski, P. J., Godbout, J. P., & López, M. G. (2021). Central Activation of Alpha7 Nicotinic Signaling Attenuates LPS-Induced Neuroinflammation and Sickness Behavior in Adult but Not in Aged Animals. Molecules (Basel, Switzerland), 2021 Apr 7;26(8):2107. doi: 10.3390/molecules26082107.
Witcher, KG, Bray, CE, O’Neil, SM, Chunchai, T, Campbell, A., Zhao, F., Gordillo, A., McKim, DB, Liu, X., Dziabis, JE Quan, N. Eiferman, DE Kokiko-Cochran, ON, Askwith, C., Fischer, A, and Godbout, JP (2021). Traumatic Brain Injury causes Chronic Cortical Inflammation and Neuronal dysfunction mediated by Unique Trauma Associated Microglia. Journal of Neuroscience 2021 Feb 17;41(7):1597-1616. doi: 10.1523/JNEUROSCI.2469-20.2020. Epub 2021 Jan 15.
Witcher, KG, Dziabis, JE, Bray, CE, Gordillo AJ, Kumar, JE, Eiferman, DS, Godbout, JP and Kokiko-Cochran, ON. (2020) Comparison between Midline and Lateral Fluid Percussion Injury in Mice Reveals Prolonged but Divergent Cortical Neuroinflammation. Brain Res. 2020 Nov 1;1746:146987;1746:146987. doi: 10.1016/j.brainres.2020.146987.
Epub 2020 Jun 24.
DiSabato, D, Nemeth, D, Liu, X, Witcher, KG, O, Neil, S., Oliver, B, Sheridan, JF, Godbout, JP, and Quan N. (2020) Interleukin-1 receptor on hippocampal neurons drives social withdrawal and cognitive deficits after chronic social stress. Mol Psychiatry. 2021 Sep;26(9):4770-4782. doi: 10.1038/s41380-020-0788-3. Epub 2020 May 22
Thies KA, Hammer AM, Hildreth BE, Steck SA, Spehar JM, Kladney RD, Geisler JM, Das M, Russell LO, Bey JF, Bolyard CM, Pilarski R, Trimboli AJ, Cuitiño MC, Koivisto CS, Stover DG, Schoenfield L, Otero J, Godbout J, Chakravarti A, Ringel MD, Ramaswamy B, Li Z, Kaur B, Leone G, Ostrowski MC, Sizemore ST, Sizemore GM. (2020) Stromal platelet-derived growth factor receptor-β signaling promotes breast cancer metastasis in the brain. Cancer Res. 2021 Feb. pii: canres.3731.2019. doi: 10.1158/0008-5472.CAN-19-3731. Epub 2020 Apr 23
Tapp ZM, Kumar JE, Witcher KG, Atluri RR, Velasquez JA, O'Neil SM, Dziabis JE, Bray CE, Sheridan JF, Godbout JP, Kokiko-Cochran ON. (2020) Sleep disruption exacerbates and prolongs the inflammatory response to traumatic brain injury J Neurotrauma. 2020 Aug;10.1089/neu.2020.7010. doi:10.1089/neu.2020.7010. Epub 2020 Apr 21
Saber M, Giordano KR, Hur Y, Ortiz JB, Morrison H, Godbout JP, Murphy SM, Lifshitz J, Rowe RK. (2019) Acute peripheral inflammation and post-traumatic sleep differ between sexes after experimental diffuse brain injury. The European Journal of Neuroscience, 2020 Jul;52(1):2791-2814. doi: 10.1111/ejn.14611. Epub 2019 Nov 27.
Zhu L, Liu X, Nemeth DP, DiSabato DJ, Witcher KG, McKim DB, Oliver B, Le X, Gorantla G, Berdysz O, Li J, Ramani AD, Chen Z, Wu D, Godbout JP, Quan N. (2019) Interleukin-1 causes CNS inflammatory cytokine expression via endothelia-microglia bi-cellular signaling. Brain, behavior, and immunity. 2019 Oct. pii: S0889-1591(18)30762-1. doi: 10.1016/j.bbi.2019.06.026. Epub 2019 Jun 19
Sullivan KA, Bever SR, McKim DB, Godbout JP, Sheridan JF, Obrietan K, Pyter LM. (2019) Mammary tumors compromise time-of-day differences in hypothalamic gene expression and circadian behavior and physiology in mice. Brain, behavior, and immunity. 2019 Aug;80:805-817. doi: 10.1016/j.bbi.2019.05.028. Epub 2019 May 17.
Tapp ZM, Godbout JP, Kokiko-Cochran ON. (2019) A Tilted Axis: Maladaptive Inflammation and HPA Axis Dysfunction Contribute to Consequences of TBI. Front Neurol. 2019 Apr 24;10:345. doi: 10.3389/fneur.2019.00345. eCollection 2019.
Liu X, Nemeth DP, McKim DB, Zhu L, DiSabato DJ, Berdysz O, Gorantla G, Oliver B, Witcher KG, Wang Y, Negray CE, Vegesna RS, Sheridan JF, Godbout JP, Robson MJ, Blakely RD, Popovich PG, Bilbo SD, Quan N. (2019) Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities. Immunity. 2019 Mar 19;50(3):764-766. doi: 10.1016/j.immuni.2019.02.012.
Witcher KG, Yin W, Sheridan JF, Godbout JP. Reply to: Microglia, Monocytes, and the Recurrence of Anxiety in Stress-Sensitized Mice. Biol Psychiatry. 2019 Jun 15;85(12):e69-e70. doi: 10.1016/j.biopsych.2019.01.026. Epub 2019 Mar 8.
Yin W, Gallagher NR, Sawicki CM, McKim DB, Godbout JP, Sheridan JF. (2019) Repeated social defeat in female mice induces anxiety-like behavior associated with enhanced myelopoiesis and increased monocyte accumulation in the brain. Brain Behav Immun. 2019 May;78:131-142. doi: 10.1016/j.bbi.2019.01.015. Epub 2019 Jan 23.
Liu X, Nemeth DP, McKim DB, Zhu L, DiSabato DJ, Berdysz O, Gorantla G, Oliver B, Witcher KG, Wang Y, Negray CE, Vegesna RS, Sheridan JF, Godbout JP, Robson MJ, Blakely R, Popovich PG, Bilbo SD, Quan N. (2019) Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities. Immunity. 2019 Feb 19;50(2):317-333.e6. doi: 10.1016/j.immuni.2018.12.012. Epub 2019 Jan 22.
Sawicki CM, Kim JK, Weber MD, Faw TD, McKim DB, Madalena KM, Lerch JK, Basso DM, Humeidan ML, Godbout JP, Sheridan JF. (2019) Microglia Promote Increased Pain Behavior through Enhanced Inflammation in the Spinal Cord during Repeated Social Defeat Stress. J Neurosci. 2019 Feb 13;39(7):1139-1149. doi: 10.1523/JNEUROSCI.2785-18.2018. Epub 2018 Dec 17.
Aten S, Page CE, Kalidindi A, Wheaton K, Niraula A, Godbout JP, Hoyt KR, Obrietan K. Data highlighting the expression of two miR-132/212 target genes-Sirt1 and Pten-after chronic stress. Data Brief. 2018 Nov 13;21:2323-2329. doi: 10.1016/j.dib.2018.11.042. eCollection 2018 Dec.
Weber MD, McKim DB, Niraula A, Witcher KG, Yin W, Sobol CG, Wang Y, Sawicki CM, Sheridan JF, Godbout JP. The Influence of Microglial Elimination and Repopulation on Stress Sensitization Induced by Repeated Social Defeat. Biol Psychiatry. 2019 Apr 15;85(8):667-678. doi: 10.1016/j.biopsych.2018.10.009. Epub 2018 Oct 25.
McKim DB, Yin W, Wang Y, Cole SW, Godbout JP, Sheridan JF. Social Stress Mobilizes Hematopoietic Stem Cells to Establish Persistent Splenic Myelopoiesis.
Cell Rep. 2018 Nov 27;25(9):2552-2562.e3. doi: 10.1016/j.celrep.2018.10.102.
O'Neil SM, Witcher KG, McKim DB, Godbout JP. Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues
driving priming to immune challenge. Acta Neuropathol Commun. 2018 Nov 26;6(1):129. doi: 10.1186/s40478-018-0636-8.
Niraula A, Witcher KG, Sheridan JF, Godbout JP. Interleukin-6 Induced by Social Stress Promotes a Unique Transcriptional Signature in the Monocytes That
Facilitate Anxiety. Biol Psychiatry. 2018 Oct 10. pii: S0006-3223(18)31929-2. doi: 10.1016/j.biopsych.2018.09.030.
Witcher KG, Bray CE, Dziabis JE, McKim DB, Benner BN, Rowe RK, Kokiko-Cochran ON, Popovich PG, Lifshitz J, Eiferman DS, Godbout JP. Traumatic brain
injury-induced neuronal damage in the somatosensory cortex causes formation of rod-shaped microglia that promote astrogliosis and persistent neuroinflammation.
Glia. 2018 Oct 30. doi: 10.1002/glia.23523.
Aten S, Page CE, Kalidindi A, Wheaton K, Niraula A, Godbout JP, Hoyt KR, Obrietan K. miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior. Neuropharmacology. 2019 Jan;144:256-270. doi: 10.1016/j.neuropharm.2018.10.020. Epub 2018 Oct 18.
Norden DM, Faw TD, McKim DB, Deibert RJ, Fisher LC, Sheridan JF, Godbout JP, Basso DM Ed.D. , PT. Bone Marrow-derived Monocytes Drive the Inflammatory Microenvironment in Local and Remote Regions after Thoracic SCI. J Neurotrauma. 2018 Jul 17. doi: 10.1089/neu.2018.5806. Epub 2018 Oct 6.
Lisboa SF, Niraula A, Resstel LB, Guimaraes FS, Godbout JP, Sheridan JF. Repeated social defeat-induced neuroinflammation, anxiety-like behavior and resistance to fear extinction were attenuated by the cannabinoid receptor agonist WIN55,212-2. Neuropsychopharmacology. 2018 Aug;43(9):1924-1933. doi: 10.1038/s41386-018-0064-2. Epub 2018 Apr 17.
Kokiko-Cochran, O. N., & Godbout, J. P. (2018). The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease. Frontiers in Immunology, 9, 672. http://doi.org/10.3389/fimmu.2018.00672
Niraula, A., Wang, Y., Godbout, J. P., & Sheridan, J. F. (2018). Corticosterone Production during Repeated Social Defeat Causes Monocyte Mobilization from the Bone Marrow, Glucocorticoid Resistance, and Neurovascular Adhesion Molecule Expression. The Journal of Neuroscience, 38(9), 2328–2340. http://doi.org/10.1523/JNEUROSCI.2568-17.2018
Sawicki, CM., Kim, J. ,Weber, MD, Jarrett, Godbout, JP, Sheridan, JF., and Humeidan, M. (2018) Ropivacaine and Bupivacaine Prevent Increased Pain Sensitivity Without Altering Neuroimmune Activation Following Repeated Social Defeat Stress. Brain Behavior and Immunity, 2018 Mar;69:113-123. doi: 10.1016/j.bbi.2017.11.005. Epub 2017 Nov 8.
Kim, B., Kusibati, R., Heisler-Taylor, T., Mantopoulos, D., Ding, J., Abdel-Rahman, M.H., Satoskar, A., Godbout, J.P., Bhattacharya, SK. And Cebulla, C. (2018) MIF Inhibitor ISO-1 Protects Photoreceptors and Reduces Gliosis in Experimental Retinal Detachment Nature Scientific Reports, 2017 Oct;7:14336 (2017).
Pyter LM, McKim DB, Husain Y, Calero H, Godbout JP, Sheridan JF, Marucha PT, Engeland CG. Effects of dermal wounding on distal primary tumor immunobiology in mice. (2018). J Surg Res. 2018 Jan;221:328-335. doi: 10.1016/j.jss.2017.09.016. Epub 2017 Oct 17.
McKim, D. B., Weber, M. D., Niraula, A., Sawicki, C. M., Liu, X., Jarrett, B. L., … Godbout, J. P. (2018). Microglial recruitment of IL-1β producing monocytes to brain endothelium causes stress-induced anxiety. Molecular Psychiatry, 23(6), 1421–1431. http://doi.org/10.1038/mp.2017.64
Witcher KG, Godbout JP. Can Sustained Glia-Mediated Brain Inflammation After Repeated Concussive Brain Injury Be Detected In Vivo?. JAMA Neurol. 2017;74(1):23–25. doi:10.1001/jamaneurol.2016.4539
Bolyard, C., Meisen, W. H., Banasavadi-Siddegowda, Y., Hardcastle, J., Yoo, J. Y., Wohleb, E. S., … Kaur, B. (2017). BAI1 orchestrates macrophage inflammatory response to HSV infection- implications for oncolytic viral therapy. Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 23(7), 1809–1819. http://doi.org/10.1158/1078-0432.CCR-16-1818
Niraula, A., Sheridan, J. and Godbout, JP (2016) Microglial Priming in Aging and Stress. Invited review for Neuropsychopharmacology, Sep 8. doi: 10.1038/npp.2016.185. Epub 2016 Sep 8. (IF: 7.05)
Pyter LM, Husain Y, Calero H, McKim DB, Lin HY, Godbout, J.P. Sheridan JF, Engeland CG, Marucha PT. (2016) Tumors Alter Inflammation and Impair Dermal Wound Healing in Female Mice.PLoS One. 2016 Aug 22;11(8):e0161537. doi: 10.1371/journal.pone.0161537. (IF: 3.323)
Norden, D.M., Trojanowski, P.T, Walker, F.R., and Godbout, J.P. (2016) Insensitivity of Astrocytes to Interleukin-10 Re-programming following Peripheral Immune Challenge Results in Prolonged Microglia Activation in the Aged Brain. Neurobiology of Aging. 44:22-41I (IF: 5.013)
Weber, M. Godbout, JP and Sheridan (2016) Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal. Neuropsychopharmacology, Jul 20. doi: 10.1038/npp.2016.102. Epub 2016 Jun 20. Review (IF: 7.05)
Hansen C.N., Norden, D.M., Faw, T.D., Deibert, R., Wohleb, E.S., Sheridan, J.F., Godbout, J.P., Basso., D.M. (2016) Lumbar Myeloid Cell Trafficking into Locomotor Networks after Thoracic Spinal Cord Injury. Experimental Neurology 282:86-98 (IF 4.7)
Fonken, L., Frank, M., Kitt, M., D’Angelo, H., Norden, DM, Weber, M., Barrientos, R., Godbout, J.P., Watkins, LR & Maier, S. (2016) The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming. Journal of Neuroscience, Jul 27;36(30):7946-56. doi: 10.1523/JNEUROSCI.1161-16. (IF: 6.34)
Ziebell, JM, Rowe, RK, Muccigrosso, M., Reddaway, JT, Adelson, PD, Godbout, J.P and Lifshitz, J. (2016) Aging With a Traumatic Brain Injury: Could Behavioral Morbidities and Endocrine Symptoms be Influenced by Microglial Priming? Brain Behavior and Immunity S0889-1591(16)30053-8. doi: 10.1016/j.bbi.2016.03.008. Epub 2016 Mar 11. Review.
DiSabato, D., Quan, N., and Godbout, J.P. (2016) Neuroinflammation: The Devil is in the Details. Invited review for Journal of Neurochemistry Mar 15. doi: 10.1111/jnc.13607. Epub 2016 May 4. Review.
McKim, D., Niraula, A., Tarr, A., Wohleb, E., Sheridan, J., and Godbout, J.P. (2016) Neuroinflammatory Dynamics Underlie Memory Impairments after Repeated Social Defeat. Journal of Neuroscience, Mar 2;36(9):2590-604. doi: 10.1523/JNEUROSCI.2394-15.2016. (IF: 6.34)
Muccigrosso, M.M., Ford, J., Benner, B., Moussa, D., Burnsides, C., Fenn, A.M., Popovich, P.G., Lifshitz, J., Walker, F.R, Eiferman, D.S., and Godbout, J.P. (2016) Cognitive impairment develops 1 month after mTBI and is exaggerated by Microglia-Associated Reactivity to Peripheral Immune Challenge. Brain Behavior and Immunity (IF 6.1)
Witcher, K.G., Eiferman, D.E., and Godbout, J.P (2015) Priming the Inflammatory Pump of the CNS after Traumatic Brain Injury. Invited review for Trends in Neuroscience Oct;38(10):609-20. doi: 10.1016/j.tins.2015.08.002. Review. (IF 12.9)
Norden, D, Trojanowski, P. Villanueva, E., Navarro, E., and Godbout, J.P. (2015) “Sequential Activation of Microglia and Astrocyte Cytokine Expression Precedes Increased Iba-1 or GFAP Immunoreactivity following Systemic Immune Challenge” Glia, Feb;64(2):300-16. doi: 10.1002/glia.22930. Epub 2015 Oct 15. (IF 6.03)
McKim, D. Patterson, J., Wohleb, E., Jarrett, B., Reader, B., Godbout, J.P. and Sheridan, J.F. (2015) Sympathetic Release of Splenic Monocytes Promotes Recurring Anxiety Following Repeated Social Defeat. Biological Psychiatry (IF: 9.25)
Skendelas, J., Muccigrosso, M.M., Eiferman, D.S., and Godbout, J.P. (2015) Chronic Inflammation after TBI and Associated Behavioral Sequelae. Current Physical Medicine and Rehabilitation Reports
Meisen, MH, Wohleb, E, Jaime-Ramirez, AC, Bolyard, C, Yoo, JY, Russell, L., Hardcastle, J., Dubin, S, Godbout, JP and Kaur, B. (2015) The impact of macrophage and microglia secreted TNFα on oncolytic viral therapy in the glioblastoma tumor microenvironment. Clinical Cancer Research, 2015 July, 15. doi: 10.1158/1078-0432.CCR-14-3118. Epub 2015 Mar 31 (IF:8.2)
Reader, B., Jarrett, B., McKim, D., Wohleb, E., Godbout, J.P. and Sheridan, JF (2015) Peripheral and Central Effects of Repeated Social Defeat Stress: Monocyte Trafficking, Microglial Activation, and Anxiety. Neuroscience, 2015 Mar 19;289C:429-442. doi: 10.1016/j.neuroscience.2015.01.001. Epub 2015 Jan 14. 004 (IF 3.2)
Norden, D., Devine, R., Bicer, S., Jing, R., Reiser, P.J., Wold, L.E., Godbout, J.P., McCarthy, D.O. (2015) Fluoxetine Prevents the Development of Depressive-Like Behavior in a Mouse Model of Cancer Related Fatigue. Physiology and Behavior, 2015 Mar 1;140:230-5. doi: 10.1016/j.physbeh.2014.12.045. Epub 2014 Dec 30. (IF: 3.15)
Wohleb, E.*, McKim, D.*, Sheridan, J.F., and Godbout, J.P. (2015) Monocyte trafficking to the brain with stress and inflammation: A novel axis of immune-to-brain communication that influences mood and behavior Frontiers in Neuroscience, 2015 Jan 21;8:447. doi: 10.3389/fnins.2014.00447.
Liu X, Yamashita T, Chen Q, Belevych N, Mckim DB, Tarr AJ, Coppola V, Nath N, Nemeth DP, Syed ZW, Sheridan JF, Godbout JP, Zuo J, and Quan N. (2015) Interleukin 1 type 1 receptor restore: a genetic mouse model for studying interleukin 1 receptor-mediated effects in specific cell types. Journal of Neuroscience 2015 Feb 18;35(7):2860-70. (IF 7.1)
Norden, D., Muccigrosso, M.M., and Godbout, J.P. (2015) Microglial Priming and Enhanced Reactivity to Secondary Insult in Aging, Traumatic CNS Injury, and Neurodegenerative Disease. Neuropharmacology 2014 Nov 13. pii: S0028-3908(14)00403-1. doi: 10.1016/j.neuropharm.2014.10.028 (IF 4.7).
Sawicki, C.M., McKim, D., Wohleb, E.S., Jarrett, B.L., Reader, B., Norden, D., Godbout, J.P. and Sheridan, J.F. (2014) Social defeat promotes a reactive endothelium in a brain region-dependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain. Neuroscience. 2014 Oct 14. pii: S0306-4522(14)00858-6. doi: 10.1016/j.neuroscience.2014.10.004 (IF 3.2)
Norden, D., Bicer, S., Clark, Y., Jing, R., Henry, C.J., Wold, L., Reiser, P., Godbout, J.P. and McCarthy, DO. (2014) Tumor progression Increases Neuroinflammation, Fatigue, and Depressive-like behavior without Altering Muscle Function. Brain Behavior and Immunity. 2014 Aug 4. pii: S0889-1591(14)00405-X. doi: 10.1016/j.bbi.2014.07.013 (IF 6.1)
Fenn, AM, Skendelas, J., Moussa, D., Mucigrosso, M., Lifshitz, J., Popovich, P.G., Eiferman, D.S., and J.P. Godbout (2015) Methylene Blue Attenuates Traumatic Brain Injury Associated Neuroinflammation and Acute Depressive-like Behavior in mice. Journal of Neurotrauma . 2015 Jan 15;32(2):127-38. doi: 10.1089/neu.2014.3514. Epub 2014 Nov 13. (IF 4.7)
Fenn, A.M., Hall, J., Gensel, J., Popovich, P.G., and Godbout, J.P. (2014) IL-4 Signaling Drives a Unique Arginase+/IL-1β+Microglia Phenotype and Recruits Macrophages to the Inflammatory CNS: Consequences of Age-Related Deficits in IL-4Rα after Traumatic Spinal Cord Injury. Journal of Neuroscience 34(26):8904-8917 (IF 7.1)
Norden, D., Fenn, A.M, Dugan, A., and Godbout, J (2014) TGFbeta produced by IL-10 re-directed Astrocytes Attenuates Microglial Activation. Glia, Jun;62(6):881-95. doi: 10.1002/glia.22647. (IF 5.1)
Frakes, A.E., Ferraiuolo, l., Haidet-Phillips, A.M., Schmelzer, L., Braun, L., Miranda, C. J., Bevan, A., Foust, K.D., Godbout, J.P., Popovich, P.G., Guttridge, D.C., and Kaspar, BK. (2014) Microglia induce motor neuron death via the classical NF-kB pathway in ALS. Neuron Mar 5;81(5):1009-23. doi: 10.1016/j.neuron.2014.01.013. (IF 15.7)
Wohleb, E., Patterson, J.M., Sharma, V., Quan, N., Godbout, J.P. and Sheridan, J.F. (2014) Knock-down of interleukin-1 receptor type-1 (IL-1R1) on endothelial cells ameliorated stress-induced neuroinflammation and prevented anxiety-like behavior. Journal of Neuroscience, 34(7) 2583-2591 (IF 7.1)
Wohleb, E., McKim, D., Shea, D., Tarr, A., Sheridan, J., and Godbout, J.P. (2014) Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain. Biological Psychiatry Dec 10. pii: S0006-3223(13)01072-X. doi: 10.1016/j.biopsych.2013.11.029 (IF 9.25)
Fenn, A.M., Gensel, J., Huang, Y., Popovich, P.G., Lifshitz, J., and Godbout, J.P. (2014) Immune activation promotes depression one month after brain injury: a role for primed microglia. Biological Psychiatry 2013 Oct 25. doi:pii: S0006-3223(13)00950-5. 10.1016/j.biopsych.2013.10.014. (IF 9.25)
Lieblein-Boff, J., McKim, D., Shea, D., Sawicki, C., Deng, Z., Bilbo, S.D., Bailey, M., Quan, N., McTigue, D., and Godbout, J.P. (2013) Neonatal E.coli infection causes neuro-behavioral deficits associated with hypomyelination and neuronal sequestration of iron. Journal of Neuroscience, Oct 9;33(41):16334-45. doi: 10.1523/JNEUROSCI.0708-13.2013. (IF 7.1)
Wohleb, E.S., Powell, N.D., Godbout, J.P., and Sheridan, J.F. (2013) Stress-Induced Recruitment of Bone Marrow-Derived Monocytes to the Brain Promotes Anxiety-Like Behavior. Journal of Neuroscience, Aug 21;33(34):13820-33. doi: 10.1523/JNEUROSCI.1671-13.2013. (IF 7.1)
Fenn, A.M., Smith, K Lovett-Racke, A, Gurau-de-Arellano, M., Whitacre C, and Godbout, J.P (2013). Increased miR-29b in the aged brain correlates with the reduction of IGF-1 and CX3CL1. Neurobiology of Aging EpubJul 20. doi:pii: S0197-4580(13)00262-5. 10.1016/j.neurobiolaging.2013.06.007. (IF 6.1).
Gomez-Nicola D, Teeling J, Guaza C, Godbout JP, Taub DD. (2013) The Role of Inflammatory Mediators in Immune-to-Brain Communication during Health and Disease. Mediators of Inflammation. 2013:429231. doi: 10.1155/2013/429231. Epub 2013 Sep 10.
Brothers, H.M., Bardou, I., Hopp, S.C., Kaercher, R.M., Corona, A.W.,Fenn, A.M., Godbout, J.P. and Wenk, G.L. (2013) “Riluzole Partially Rescues Age-Associated, but not LPS-Induced, Loss of Glutamate Transporters and Spatial Memory.” Journal of Neuroimmune Pharmacology. EpubMay 25. (IF 4.57).
Voorhees JL, Tarr AJ, Wohleb ES, Godbout JP, Mo X, Sheridan JF, Eubank, TD, Marsh CB. (2013) “Prolonged Restraint Stress Increases IL-6, Reduces IL-10,and Causes Persistent Depressive-like Behavior that is Reversed by Recombinant IL-10” PLoS One. 2013;8(3): PMC3592793 (IF 4.4).
Corona, A.W.,Skendelas, J., Norden, D., Huang, Y., O’Connor, J.C., Lawson, M., Dantzer, R., Kelley, K., and Godbout, J.P. (2013) “Indoleamine-2,3-dioxygenase inhibitionattenuates lipopolysaccharide induced persistent microglial activation anddepressive-like complications in fractalkine receptor (CX3CR1)-deficientmice”. Brain, Behavior, and Immunity. Jul;31:134-42. PMC3554840. (IF 5.6).
Norden,D. and Godbout, JP. (2013) “Microglia of the Aged Brain: Primed to be Activated and Resistant to Regulation”. Neuropathology and Applied Neurobiology. Invited review for a Special Issue on thetopic of “Neuroinflammation in Neurodegeneration”. 2013 Feb;39(1):19-34. PMC3553257 (IF 3.95).
Wohleb, E.S., Fenn,A.M., Pacenta, A., Powell, N., Sheridan, J.F., and Godbout, J.P. (2012) “Peripheral lipopolysaccharide (LPS) injection
exaggerated microglial activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice”. PsychoNeuroEndocrinology. Sept;37(9):1491-505. PMC3368999 (IF 5.2).
Fenn, A.M., Henry, C., Huang, Y, Dugan, A., and Godbout, J.P. (2012) "Lipopolysaccharide-induced interleukin (IL)-4 receptor-alpha expression and corresponding sensitivity to the M2 promotingeffects of IL-4 are impaired in microglia of aged mice”. Brain, Behavior, and Immunity, Jul;26(5):766-77. PMC3288757 (IF 5.6).
Corona, A.W., Fenn, A.M., and Godbout,J.P. (2012) “Cognitive andbehavioral consequences of impaired immunoregulation in aging”. Journal
of Neuroimmune Pharmacology, Mar, 7(1), 7-23. (IF 3.5).
Wohleb, E., Hanke, M., Corona, A., Powell, N., Stiner, L.,Bailey, MT, Nelson, R., Godbout, JP, and Sheridan, JF (2011) "β-Adrenergic Antagonism
Prevents Anxiety-like Behavior and CNS Macrophage/Microglial Reactivity Induced by Repeated Social Defeat. Journal of Neuroscience". Vol. 31,
no. 17. (April 27): 6277-6288. PMC3160240 (IF 7.2).
Corona,A.W., Huang, Y., O’Connor, J.C., Dantzer, R., Kelley, K., Popovich, PG, and Godbout, J.P. (2010) "Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide". Journal of Neuroinflammation. 7:93. PMC3018416 (IF 4.6).
Wynne, A., Henry, C.J., Huang, Y., Cleland, A., Godbout, J.P. (2010) "Protracted downregulation of CX3CR1 on microglia of aged mice after
lipopolysaccharide challenge". Brain,Behavior, and Immunity, Oct 24(7): 1190-1201. PMC2939290. (IF 5.1).
Wynne, A.,Henry, C.J. and Godbout, J.P. (2009) "Immune and behavioral consequences of microglial reactivity in the aged brain". Integrative
and Comparative Biology. 49, 254-266 (IF 2.66).
Godbout, J.P. and Johnson, R.W. (2009) "Age and neuroinflammation: a lifetime of psychoneuroimmune consequences". Immunol Allergy Clin North Am.May;29(2):321-37. (IF 2.34).
Henry, C.J., Huang, Y., Wynne, A., and Godbout, J.P. (2009) "Peripheral Lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1b and anti-inflammatory IL-10 cytokines". Brain, Behavior, and Immunity. 23:309-317. PMC2692986 (IF 4.7).
Henry,C.J., Huang, Y., Wynne, A., Hanke, M., Himler, J., Bailey, M., Sheridan, J. and Godbout, J.P. (2008) "Minocycline attenuates lipopolysaccharide-induced neuroinflammation, sickness behavior, andanhedonia". Journal of Neuroinflammation, May 13;5:15. PMC2412862 (IF 4.77).
Godbout, J.P., Moreau, M., Lestage, J., Sparkman, N., Chen, J., O’ Connor, J., Castanon, N., Kelley, K.W., Dantzer, R., and Johnson, RW (2008) "Aging exacerbates depressive like-behavior in mice in response to activation of the peripheral innate immune system". Neuropsychopharmacology, Sep;33(10):2341-51. PMC2907915 (IF 6.35).
Abraham, J., Jang, S., Godbout, J.P., Chen, J., and Johnson, R.W. (2008) "Aged mice are more sensitive to behavioral deficits induced by central
HIV-1 gp120". Neurobiology of Aging. 29,614-621. (IF 5.6).
Chen,J., Buchanan, J.B., Sparkman, N.L. Godbout, J.P., Freund, G., and Johnson, R.W. (2008) "Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system". Brain, Behavior, and Immunity. 22, 301-311. (IF 5.1).
Huang, Y., Henry,C.J., Dantzer, R, Johnson, R.W., and Godbout,J.P. (2008) "Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide". Neurobiology of Aging, Nov;29(11):1744-53. PMC2647751. (IF 5.6).
Gaykema, R.P.A., Balachandran, M.K., Godbout, J.P., Johnson R.W., and Goehler,L.E. (2007) "Enhanced neuronal activation in central autonomic network nuclei of aged mice following acute peripheral immune challenge". Autonomic Neuroscience,Jan30;131(1-2):137-142. (IF 1.85).
Godbout,J.P. and Glaser, R. (2006) "Stress-Induced Immune Dysregulation: Implications for Wound Healing, Infectious Disease and Cancer". Journal of Neuroimmune Pharmacology1, 421-427.
Godbout,J.P. and Johnson, R.W. (2006) "Age and neuroinflammation: a lifetime of psychoneuroimmune consequences". Neurologic Clinics, 24, 512-538. (IF 2.51).
Godbout, J.P., Chen,J., Abraham, J., Richwine, A.R., Berg, B.M., Kelley,K.W., and Johnson, R.W. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system". FASEB Journal. Aug; 19(10):1329-31. (IF 6.8).
Godbout, J.P., Berg, B.M., Krzyszton, C., and Johnson, R.W. (2005). "a-Tocopherol attenuates NFkB activation andpro-inflammatory cytokine production in brain and improves recovery from lipopolysaccharide-induced sickness behavior". Journal of Neuroimmunology. 169, 97-105. (IF 3.4).
Richwine, A.R., Godbout, J.P, Chen, J., Berg, B.M., Escobar, J.,Millard, D.K., and. Johnson, R.W. (2005) "Improved psychomotor performance in aged mice fed diet high in antioxidants is associated with reduced ex vivo interleukin-6 production". Brain, Behavior, and Immunity. 19, 512-520. (IF 5.1).
Berg, B.M., Godbout, J.P., Chen, J.,Kelley, K.W., and Johnson, R.W. (2005) "a-Tocopherol and Selenium facilitate recovery from lipopolysaccharide-induced sicknessbehavior in aged mice". Journal ofNutrition, 135, 1157-1163 (IF 3.25).
Godbout, J.P., Berg, B.M., Kelley, K.W., and Johnson, R.W. (2004) "a-Tocopherol reduceslipopolysaccharide-induced peroxide radical accumulation and interleukin-6 secretion in primary murine microglia and in brain". Journal of Neuroimmunology. 149, 101-109. (IF 3.34).
Godbout, J.P. and Johnson, R.W. (2004) "Interleukin-6 in the Aging Brain". Journal of Neuroimmunology. 147, 141-144. (IF 3.34).
Berg, B.M., Godbout, J.P., Kelley, K.W., and Johnson, R.W. (2004) "a-Tocopherol attenuates lipopolysaccharide-induced sickness behavior in mice". Brain, Behavior, andImmunity. 18, 149-157. (IF 4.7).
Hartman, M.E.,O’Connor J.C., Godbout, J.P., Minor, K.D., Mazzocco, V.R. and Freund, G.G. (2004) "Insulin Receptor Substrate-2-Dependent Interleukin-4 Signaling in Macrophages isImpaired in Two Models of Type 2 Diabetes Mellitus". Journal of Biological Chemistry. 279: 28. (IF 6.35).
Godbout, J.P., Pesavento, J., Hartman, M.E., Manson, S.R.,and Freund, G.G. (2002) "Methylglyoxal Enhances Cisplatin-Induced Cytotoxicity By Activating PKCd". Journal of BiologicalChemistry. 277: 2554-2561. (IF 6.35).
Godbout, J.P., Cengel, K.A., Cheng, S., Minshall, C.,Kelley, K.W., and Freund, G.G. (1999) "Insulin activates caspase-3 by a phosphatidylinositol 3’-kinase dependent pathway". Cellular Signalling. 11:15-23. (IF 4.7).
Cengel, K.A., Godbout, J.P.,and Freund, G.G. (1998) "Phosphatidylinositol 3'-kinase is associated with a serine kinase that is activated by okadaic acid". Biochemical and BiophysicalResearch Communications. 242: 513-517. (IF 2.94).